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Secondary leukemia

MedGen UID:
488688
•Concept ID:
C0856053
•
Neoplastic Process

Professional guidelines

PubMed

Mechanisms of Secondary Leukemia Development Caused by Treatment with DNA Topoisomerase Inhibitors.
Lomov NA, Viushkov VS, Rubtsov MA
Biochemistry (Mosc) 2023 Jul;88(7):892-911. doi: 10.1134/S0006297923070040. PMID: 37751862
ENABLE: treatment combination including decitabine and venetoclax in acute myeloid leukemia secondary to myeloproliferative neoplasms.
Mannelli F, Guglielmelli P, Fazi P, Crea E, Piciocchi A, Vignetti M, Amadori S, Pane F, Venditti A, Vannucchi AM
Future Oncol 2023 Jan;19(2):103-111. Epub 2023 Jan 18 doi: 10.2217/fon-2022-0512. PMID: 36651780
Integration of Molecular Information in Risk Assessment of Patients with Myeloproliferative Neoplasms.
Loscocco GG, Coltro G, Guglielmelli P, Vannucchi AM
Cells 2021 Aug 2;10(8) doi: 10.3390/cells10081962. PMID: 34440731Free PMC Article

Recent clinical studies

Etiology

Associations Between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients With Solid Tumors.
Franch-Expósito S, Mehine M, Ptashkin RN, Bolton KL, Bandlamudi C, Srinivasan P, Zhang L, Goodell MA, Gedvilaite E, Menghrajani K, Sánchez-Vela P, Mandelker D, Comen E, Norton L, Benayed R, Gao T, Papaemmanuil E, Taylor B, Levine R, Offit K, Stadler Z, Berger MF, Zehir A
JCO Precis Oncol 2023 Aug;7:e2300070. doi: 10.1200/PO.23.00070. PMID: 37561983Free PMC Article
Classical Hodgkin Lymphoma: From Past to Future-A Comprehensive Review of Pathophysiology and Therapeutic Advances.
Munir F, Hardit V, Sheikh IN, AlQahtani S, He J, Cuglievan B, Hosing C, Tewari P, Khazal S
Int J Mol Sci 2023 Jun 13;24(12) doi: 10.3390/ijms241210095. PMID: 37373245Free PMC Article
First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial.
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602
Therapy-associated solid tumors.
Travis LB
Acta Oncol 2002;41(4):323-33. doi: 10.1080/028418602760169361. PMID: 12234023
The 5q-anomaly.
Van den Berghe H, Vermaelen K, Mecucci C, Barbieri D, Tricot G
Cancer Genet Cytogenet 1985 Jul;17(3):189-255. doi: 10.1016/0165-4608(85)90016-0. PMID: 3891074

Diagnosis

'Secondary' acute lymphoblastic/lymphocytic leukemia - done playing second fiddle?
Riazat-Kesh YJRA, Mascarenhas J, Bar-Natan M
Blood Rev 2023 Jul;60:101070. Epub 2023 Mar 5 doi: 10.1016/j.blre.2023.101070. PMID: 36894417
Genetics of progression from MDS to secondary leukemia.
Menssen AJ, Walter MJ
Blood 2020 Jul 2;136(1):50-60. doi: 10.1182/blood.2019000942. PMID: 32430504Free PMC Article
Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA).
Brown AL, Hahn CN, Scott HS
Blood 2020 Jul 2;136(1):24-35. doi: 10.1182/blood.2019000937. PMID: 32430494Free PMC Article
Therapy-associated solid tumors.
Travis LB
Acta Oncol 2002;41(4):323-33. doi: 10.1080/028418602760169361. PMID: 12234023
Lessons from our children.
Donaldson SS
Int J Radiat Oncol Biol Phys 1993 Aug 1;26(5):739-49. doi: 10.1016/0360-3016(93)90487-g. PMID: 8344841

Therapy

Classical Hodgkin Lymphoma: From Past to Future-A Comprehensive Review of Pathophysiology and Therapeutic Advances.
Munir F, Hardit V, Sheikh IN, AlQahtani S, He J, Cuglievan B, Hosing C, Tewari P, Khazal S
Int J Mol Sci 2023 Jun 13;24(12) doi: 10.3390/ijms241210095. PMID: 37373245Free PMC Article
Etoposide: A rider on the cytokine storm.
Bailly C
Cytokine 2023 Aug;168:156234. Epub 2023 Jun 1 doi: 10.1016/j.cyto.2023.156234. PMID: 37269699
Genetics of progression from MDS to secondary leukemia.
Menssen AJ, Walter MJ
Blood 2020 Jul 2;136(1):50-60. doi: 10.1182/blood.2019000942. PMID: 32430504Free PMC Article
First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial.
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602
Therapy-associated solid tumors.
Travis LB
Acta Oncol 2002;41(4):323-33. doi: 10.1080/028418602760169361. PMID: 12234023

Prognosis

Classical Hodgkin Lymphoma: From Past to Future-A Comprehensive Review of Pathophysiology and Therapeutic Advances.
Munir F, Hardit V, Sheikh IN, AlQahtani S, He J, Cuglievan B, Hosing C, Tewari P, Khazal S
Int J Mol Sci 2023 Jun 13;24(12) doi: 10.3390/ijms241210095. PMID: 37373245Free PMC Article
'Secondary' acute lymphoblastic/lymphocytic leukemia - done playing second fiddle?
Riazat-Kesh YJRA, Mascarenhas J, Bar-Natan M
Blood Rev 2023 Jul;60:101070. Epub 2023 Mar 5 doi: 10.1016/j.blre.2023.101070. PMID: 36894417
Genetics of progression from MDS to secondary leukemia.
Menssen AJ, Walter MJ
Blood 2020 Jul 2;136(1):50-60. doi: 10.1182/blood.2019000942. PMID: 32430504Free PMC Article
First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial.
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602
The 5q-anomaly.
Van den Berghe H, Vermaelen K, Mecucci C, Barbieri D, Tricot G
Cancer Genet Cytogenet 1985 Jul;17(3):189-255. doi: 10.1016/0165-4608(85)90016-0. PMID: 3891074

Clinical prediction guides

A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis.
Li R, Colombo M, Wang G, Rodriguez-Romera A, Benlabiod C, Jooss NJ, O'Sullivan J, Brierley CK, Clark SA, Pérez Sáez JM, Fernández PA, Schoof EM, Porse B, Meng Y, Khan AO, Wen S, Dong P, Zhou W, Sousos N, Murphy L, Clarke M, Olijnik AA, Wong ZC, Karali CS, Sirinukunwattana K, Ryou H, Norfo R, Cheng Q, Carrelha J, Ren Z, Thongjuea S, Rathinam VA, Krishnan A, Royston D, Rabinovich GA, Mead AJ, Psaila B
Sci Transl Med 2024 Oct 9;16(768):eadj7552. doi: 10.1126/scitranslmed.adj7552. PMID: 39383242Free PMC Article
Associations Between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients With Solid Tumors.
Franch-Expósito S, Mehine M, Ptashkin RN, Bolton KL, Bandlamudi C, Srinivasan P, Zhang L, Goodell MA, Gedvilaite E, Menghrajani K, Sánchez-Vela P, Mandelker D, Comen E, Norton L, Benayed R, Gao T, Papaemmanuil E, Taylor B, Levine R, Offit K, Stadler Z, Berger MF, Zehir A
JCO Precis Oncol 2023 Aug;7:e2300070. doi: 10.1200/PO.23.00070. PMID: 37561983Free PMC Article
Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA).
Brown AL, Hahn CN, Scott HS
Blood 2020 Jul 2;136(1):24-35. doi: 10.1182/blood.2019000937. PMID: 32430494Free PMC Article
DNA methylation as a pathogenic event and as a therapeutic target in AML.
Schoofs T, Müller-Tidow C
Cancer Treat Rev 2011;37 Suppl 1:S13-8. Epub 2011 May 25 doi: 10.1016/j.ctrv.2011.04.013. PMID: 21612874
Lessons from our children.
Donaldson SS
Int J Radiat Oncol Biol Phys 1993 Aug 1;26(5):739-49. doi: 10.1016/0360-3016(93)90487-g. PMID: 8344841

Recent systematic reviews

Chronic Myeloid Leukemia following Exposure to Radioactive Iodine (I131): A Systematic Review.
Ali Hailan YM, Al-Dubai HN, Yassin MA
Oncology 2023;101(6):362-368. Epub 2023 May 9 doi: 10.1159/000530463. PMID: 37231874
Risk of second primary cancers in cancer patients treated with cisplatin: a systematic review and meta-analysis of randomized studies.
Liang F, Zhang S, Xue H, Chen Q
BMC Cancer 2017 Dec 19;17(1):871. doi: 10.1186/s12885-017-3902-4. PMID: 29258467Free PMC Article
Gene therapy as a new treatment option for inherited monogenic diseases.
Boudes PF
Eur J Intern Med 2014 Jan;25(1):31-6. Epub 2013 Oct 12 doi: 10.1016/j.ejim.2013.09.009. PMID: 24129166

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